Synthesis of γ-Lactone-Type Sialic Acid, an Isomer of 2,3-Dehydrosialic Acid
نویسندگان
چکیده
منابع مشابه
Microbial synthesis of triacetic acid lactone.
Native g2ps1-encoded 2-pyrone synthase (2-PS) from Gerbera hybrida, a mutant Brevibacterium ammoniagenes fatty acid synthase B (FAS-B) and two different mutants of Penicillium patulum 6-methylsalycilic acid synthase (6-MSAS) are examined to identify the best enzyme to recruit for the microbial synthesis of triacetic acid lactone (TAL). To identify the best microbial host for these evaluations, ...
متن کاملAsymmetric Synthesis of Homocitric Acid Lactone.
A short, diastereoselective synthesis of homocitric acid lactone is described. The key step is a bioinspired aldol addition to set the stereogenic center in an intermediate that requires only modest oxidation state manipulation to complete the synthesis. This approach enables rapid generation of isotopomers in which carbon and hydrogen can be replaced by heavier nuclei at nearly every position.
متن کاملEnzymatic synthesis of sialic acid 9-phosphates.
7Jourdian, G. W., and S. Roseman, Abstracts, 137th Meeting of the American Chemical Society, 1960, p. 47C. 8 Byrne, W. L., and H. A. Lardy, Biochim. et Biophys. Acta, 14, 495-601 (1954). 9 Dische, Z., and Borenfreund, E., J. Biol. Chem., 180, 1297-1300 (1949). 10 Ballou, C. E., Arch. Biochem. & Biophys., 78, 328-333 (1958). 11 Warren, L., and H. Felsenfeld, Biochem. Biophys. Res. Comm., 4, 232-...
متن کاملSialic acid and N-acetylglucosamine Regulate type 1 Fimbriae Synthesis.
Type 1 fimbriae of E. coli, a chaperon-usher bacterial adhesin, are synthesized by the majority of strains of the bacterium. Although frequently produced by commensal strains, the adhesin is nevertheless a virulence factor in Extraintestinal Pathogenic E. coli (ExPEC). The role of the adhesin in pathogenesis is best understood in Uropathogenic E. coli (UPEC). Host attachment and invasion by typ...
متن کاملDe novo chemoenzymatic synthesis of sialic acid.
A chemoenzymatic synthesis of sialic acid from inexpensive N-acetyl-D-glucosamine is described. In a three-step Wittig-protection-ozonolysis strategy manno-configured aldehydes are obtained. Treatment with oxaloacetate in the presence of macrophomate synthase affords the signature α-keto-γ-hydroxy acid moiety with high diastereoselectivity.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bioscience, Biotechnology, and Biochemistry
سال: 2010
ISSN: 0916-8451,1347-6947
DOI: 10.1271/bbb.90912